Thursday, December 8, 2011

Treating malaria by starving the parasite causing it

A new medicine in development to treat malaria focuses on killing the parasite that causes the disease by starving it. By blocking the production of a molecule that the mosquito needs to build new DNA, it can't make new cells, causing it to die. By starving it of the required building blocks for DNA, the scientists claim they have found the Achilles' heal, which aids in eradicating the bug causing malaria.

Building blocks
To make DNA, the micro-organism needs purines. To create purines, it needs another molecule, and the production of this particular molecule is inhibited by the researchers. Organisms constantly need to create new cells to replace old ones, and each cell needs a new set of freshly produced DNA, copied from the parent cells. While the parasites are not starved in the usual sense of the word, they no longer receive the right nutrients to sustain themselves.

Treatment
The purine-inhibiting drug, codenamed BCX4945, was given to a couple of primates that were infected with an otherwise lethal dose of the parasite causing malaria. The scientists found that the treatment helped the monkeys to survive. After the treatment ended, the infection seemed to return. However, the levels of parasitic activity in the body remained lower than during an untreated infection.

Alternatives
There are more studies being performed on treating malaria, which is the world's most common parasitic disease, and kills about 800.000 people worldwide each year. A vaccination programme that already started has been shown to half the incidence of severe malaria. Additionally, scientists modified the mosquito that carries the malaria-causing bug, which causes their offspring to die before reaching maturity, and thus preventing procreation.

Outlook
As stated, there are many new therapies underway to treat malaria, and they all approach the disease from different angles. That is a good thing, because deploying different strategies increases the chance of success, and it is possible that different treatments work in a synergistic way.

2 comments:

  1. Very informative article. Thanks for the sharing here!!!
    Doxycycline

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  2. God have been very kind to me, despite the hard times he made me go through but now I give him all the praise for relieving my mum of her stroke through the help of an herbal doctor by name Uwadia Amenifo. Helen Smith is my name, and we live in England. My mum was diagnosed of stroke eight months ago, and she was in so many pains as she can’t even walk, go to rest room, or move her body. She even has to excrete in her body most times. I am her only child, and I so much love my mum because my dad died when I was 4 years old. So I grew up in the hands of only my mum without fatherly care. It happened that when she was diagnosed of stroke by our family doctor her condition was still good by then, but in just one month after her diagnoses, her condition became very worst that the doctor then said her stroke is acute and no longer partial. And that it will only take God’s intervention for her to be well again and for her to be able to retain the full use of her brain. So her ailment continues until God intervened before God’s intervention, I have carried her to so many churches for prayers and have traveled very far to look for a cure for her. I Travelled to America to see some doctors if they can help even if its surgery they can carry out on her provided she don’t die, because I really needed her around me. It was in America an Endocrinologist by name Jill Marie Abelseth MD from Albany, NY told me about an herbal doctor who she knows of, that have successfully cured stroke/ human parasites. So she advised me to contact the herbalist, so I contacted him, and explained to him what my mum is going through, so he counseled us and asked few questions about my mum which I told him. So he prepared the herbs, and shipped it to me in England. I gave my mum the herbs just as he has instructed, and just exactly as he said that his herbs will totally cure my mum. His herbs really worked perfectly well, and cured my mum. As I write this testimony my mum is totally cured of her stroke and she has started her normal business as usual. So I want all here to help me thank Doctor Uwadia Amenifo for his great help in helping me cure my mum of her stroke with his herbal medicine. Please if you know of anyone who have stroke or who have one disease or the other and his/her doctor says there’s no cure to that disease please I want that person to contact doctor Uwadia Amenifo, and give him a try. His contacts are Email (doctoruwadiaamenifo@gmail.com) his number is (+2349052015874), His website is http://druwadiaherbalhome.simplesite.com/ Thanks.

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